The aims of the call are:
- to support randomised interventional multi-country Investigator-Initiated Clinical Studies that are designed as pragmatic comparative-effectiveness studies and/or drug repurposing studies.
- to encourage and enable transnational collaboration between clinical/public health research teams (from hospital/ public health, healthcare settings and other healthcare organisations) that conduct multi-country IICS, either comparative-effectiveness or drug repurposing studies.

The call opens on November 6th 2025